Review Article

Link between Cancer and Alzheimer Disease via Oxidative Stress Induced by Nitric Oxide-Dependent Mitochondrial DNA Overproliferation and Deletion

Figure 5

Ultrastructural features of endothelial specific NOS (eNOS or NOS3) labeling in control (a) and metastatic liver tumors tissues (b–d) determined by using Peroxidase-anti-Peroxidase Immunocytochemistry. (a) A large number of NOS3 immunopositive EC (indicated by arrows) were seen in control liver microvessels. X5,000. (b) NOS3 immunostaining was absent in EC (asterisk) in tumor vessels. X8,000. (c) EC from tumor microvessels did not show the presence of any NOS3 immunopositive reaction. X10,000. (d) NOS3 immunopositive hepatocytes (white asterisk) in metastatic liver tumors were seen. Lipid-enriched areas were free from NOS3 positive precipitate (arrows). X8,000. Reprinted with permission of J Submicrosc Cytol Pathol [2].
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