Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models

Table 4

Effect of EPF3 on liver in hyperlipidemic golden hamsters.

Groups	Dose (mg/kg d^−1)	ALT (U/L)	AST (U/L)	SOD (U/mgprot)	GSH-Px (U/mgprot)	MDA (nmol/mgprot)
NCD	—	24.61±8.81	17.01±2.87	38.45±5.54	3819±305	0.46±0.01
HFD	—	117.8±29.09^###	71.36±12.15^###	20.42±1.41^##	2160±113^###	0.62±0.04^###
HFD + XZK	250	31.58±5.87^∗∗∗	23.41±1.78^∗∗∗	32.08±1.35^∗	3044±122^∗	0.35±0.02^∗∗∗
HFD + C100	100	21.55±5.50^∗∗∗	20.09±2.56^∗∗∗	27.62±1.78	3272±125^∗	0.35±0.01^∗∗∗
HFD + C250	250	20.20±3.15^∗∗∗	16.29±1.73^∗∗∗	31.57±3.26^∗	3693±103^∗∗	0.40±0.01^∗∗∗
HFD + C500	500	39.64±13.05^∗∗∗	27.44±4.06^∗∗∗	38.15±2.72^∗∗	2610±100	0.40±0.01^∗∗∗

Values are expressed as means ± SEM from 8 animals each group; NCD: normal chow diet group; HFD: high-fat diet group; HFD + XZK: high-fat diet + Xuezhikang group; HFD + C100, HFD + C250, HFD + C500: high-fat diet + CAF3 (100, 250, 500 mg/kg) group, respectively.
^##𝑃<0.01, ^###𝑃<0.001 compared to NCD.
^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001 compared to HFD.