Sildenafil Attenuates Hepatocellular Injury after Liver Ischemia Reperfusion in Rats: A Preliminary Study

Table 3

Effect of sildenafil pretreatment on histopathology scores, MPO staining, ICAM-1 mRNA levels (as a percentage of 𝛽-actin), and percentage of apoptotic bodies.

	Sham group (𝑛=10)	Sild+sham group (𝑛=10)	I/R group (𝑛=10)	Sild+I/R group (𝑛=10)
Histology
Hepatocellular necrosis scoring; Inflammatory infiltration scoring	1 [1-1]; 1 [1-1]	1 [1-1]; 1 [1-1]	5 [5-6]^∗; 3 [3-3]^∗	2.5 [2-3]^*#; 2 [1-2]^∗#
MPO staining scoring	0 [0-0]	0 [0-1]	3 [2-3]^∗	1 [1-1]^∗#
ICAM-1 mRNA levels (% of 𝛽-actin)	4.7±1.1	5.2±1.6	51.5±23.3^∗	17.1±5.6^∗#
Apoptotic bodies (%)	14±5	15±7	58±15^∗	32±9^∗#

Values are presented as mean ± SD for ICAM-1 mRNA levels and apoptotic bodies and as median [25th–75th percentiles] for histology and MPO staining scores.
^∗𝑃<0.05 in comparison to the sham group; ^#𝑃<0.05 in comparison to the I/R group.