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Cells involved | Intracellular signaling | Function | References |
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Intestinal epithelial cell; colon carcinoma cells (Caco2 and HT29) | IL13-Nox1-ERK/STAT6-TFF3/Bcl-xl; Nox1-RhoA-alpha3 integrin | Proliferation and differentiation; migration | [29, 36, 37, 40] |
HaCaT; GM16 | Ca2+-Nox1-PGE2; Ca2+/serum-Nox1-vimentin/K8/K18 | Proliferation and host defense; skin injury; apoptosis; migration | [17, 19, 22, 30, 31, 34, 38] |
Lung epithelial cell | Nox1-JNK/ERK/Caspase-3 | Cell death and protection | [18, 41] |
Corneal stromal fibroblast | | May participate in inflammation | [42] |
Mouse embryonic fibroblast | | Ischemia-reperfusion injury | [43] |
NIH 3T3 fibroblast; rat kidney fibroblast | Ras-Nox1-Rho-actin stress fibers and focal adhesions | Tumorigenic conversion | [15, 35] |
Fibrosarcoma L929 cells | TNF-TRADD/RIP1/Rac1/Nox1 | Necrosis | [44] |
Human BJ foreskin fibroblast and IMR-90 lung fibroblast | CCN1-Nox1/Rac-ERK/p38 MAPK-p16INK4a/pRb | Senescence and expression of antifibrotic genes | [52] |
Mouse vessel | Angiotensin II-Nox1-nitric oxide | Hypertension | [59] |
Mouse aorta | Angiotensin II-Nox1-tissue inhibitor of metalloproteinase 1 | Aortic dissection | [60] |
Human aortic endothelial cell | Hyperglycemia-Nox1-proinflammatory and profibrotic markers | Atherosclerosis | [61] |
Rat kidney cell; tumor cells and vessel; sinusoidal endothelial cell | K-Ras-Nox1-ERK-sp1-VEGF; Nox1-VEGF/VEGFR/MMP | Upregulate VEFG expression; increase tumorigenicity and upregulate VEGF/VEGFR and MMP; tubulogenic | [64, 65, 67] |
Vascular smooth muscle cell | uPA-Nox1/Nox4; PDGF-Nox1-cofilin | Migration; proliferation and necrosis | [68–70] |
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