Research Article
Melatonin Therapy Prevents Programmed Hypertension and Nitric Oxide Deficiency in Offspring Exposed to Maternal Caloric Restriction
Table 3
L-Citrulline, L-arginine, and dimethylarginine levels in the plasma and kidney.
| | Control | CR | M | CR + M |
| Plasma (μmol) | | | | | L-Citrulline | 50 ± 4.1 | 61 ± 3.6 | 59.3 ± 5.1 | 55.8 ± 6.9 | L-Arginine | 121.1 ± 14 | 84.4 ± 2.4* | 113.6 ± 8.7# | 112.8 ± 13.6# | ADMA | 1.31 ± 0.1 | 2.21 ± 0.18* | 1.18 ± 0.06# | 1.08 ± 0.12# | SDMA | 0.66 ± 0.04 | 1.62 ± 0.27* | 0.97 ± 0.09# | 0.92 ± 0.08# | L-Arginine-to-ADMA ratio | 92 ± 8 | 40 ± 4* | 98 ± 10# | 105 ± 6# | Kidney (μmol/mg protein) | | | | | L-Citrulline | 52.5 ± 8.6 | 53.1 ± 4.6 | 97.6 ± 8.4 | 68.8 ± 12.4 | L-Arginine | 425 ± 62.3 | 552.9 ± 58.9 | 522.8 ± 61.6 | 488.1 ± 56 | ADMA | 5.09 ± 0.88 | 6.33 ± 0.71 | 6.72 ± 1.03 | 4.84 ± 0.61 | SDMA | 4.3 ± 0.65 | 5.3 ± 0.51 | 5.57 ± 0.79 | 4.59 ± 0.73 | L-Arginine-to-ADMA ratio | 86 ± 4 | 89 ± 5 | 80 ± 4 | 103 ± 8$ |
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versus control; versus CR; $ versus M.
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