Reduced Oxidative Stress Contributes to the Lipid Lowering Effects of Isoquercitrin in Free Fatty Acids Induced Hepatocytes

Figure 9

Effect of IQ on the expression of the lipogenic and lipolytic genes, FAS (a), SREBP-1c (b), CPT-1 (c), and PPAR-α (d) in primary rat hepatocytes. Gene expressions of SREBP-1c and FAS were decreased while CPT-1 and PPAR-α were increased by treatment with different doses of IQ under FFA challenge. Gene expression was quantified by qRT-PCR. The results represent the average of 3 independent experiments performed in triplicate. The relative expression level is presented as the fold increase compared with the control group. The data represents ±SD. was considered as statistically significant. Different superscripts letters demonstrate the significant statistical difference as calculated by ANOVA followed by Tukey’s test.

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