The Effects of Sesquiterpenes-Rich Extract of Alpinia oxyphylla Miq. on Amyloid-β-Induced Cognitive Impairment and Neuronal Abnormalities in the Cortex and Hippocampus of Mice
Figure 4
The Morris water maze test of mice treated with vehicle, Aβ 1–42, Aβ 1–42 + donepezil (0.65 mg/kg), Aβ 1–42 + CF (180 mg/kg), and Aβ 1–42 + CF (360 mg/kg), respectively. (a) Latencies to find a hidden platform in the water maze during five consecutive training days. (b) Search strategy of mice in the second trial on the second and fifth day. Traces show the swim path of all groups of mice. (c) The time spent in the quadrant where the platform was once placed within 60 s. (d) Number of crossings over the former platform location in the probe trial. (e) and (f) The effect of CF on β-secretase activity in the frontal cortex and accumulation of Aβ 1–42 in hippocampus. (g) and (h) The effect of CF on acetylcholinesterase activity in the cortex and hippocampus of Aβ 1–42-injected mice. Data are expressed as mean ± SD. , , and versus the control mice; , , and versus the model group mice.
