Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity
Figure 3
Hypothetical oxidation of thiol and selenol groups from thioredoxin reductase (TrxR) dimers by inorganic (Te4+ and Te6+) and organic (diphenyl ditelluride [(PhTe)2] and ditelluroxide). Different tellurium forms can target both the two vicinal thiol or thiol-selenol groups in different points of the functional asymmetric dimer of the enzyme.
