Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway

Figure 4

Immunohistochemistry analysis for the effect of blueberry juice and bifidobacteria on SIRT1 expression in NAFLD rat livers (200x). CG: in control group, SIRT1 was highly expressed in nucleus with brown color. MG: in NAFLD model group, SIRT1 was lowly expressed with very light brown color. SI: in NAFLD model group with SIT1 RNAi, SIRT1 was little expressed with light blue color. BJ: in blueberry juice group, SIRT1 was highly expressed in nucleus with brown color. BJSI: in blueberry juice and SIRT1 RNAi group, the expression of SIRT1 was significantly inhibited with very light brown color. BJB: in blueberry juice and bifidobacteria group, SIRT1 was highly expressed in nucleus with brown color. BJBSI: in blueberry juice and bifidobacteria and SIRT1 RNAi group, the expression of SIRT1 was completely inhibited with blue color.