RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells

Figure 1

RCAN1^ox neurons display decreased viability upon exposure to H₂O₂. Primary neuronal cultures from E15 wild-type (light bars) and RCAN1^ox mice (dark bars) were exposed to varying concentrations (0–500 μm) of H₂O₂ for 18 hours and cell viability was measured via a standard MTT assay. 𝑛=4 neuronal cultures from individual wild-type and RCAN1^ox mice. Data presented as a percentage of the number of starting viable cells, error bars represent SEM, and ^∗∗∗𝑃<0.001.