RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells

Figure 3

RCAN1^ox cells have altered mitochondrial membrane potential in response to ROS. Wild-type (light bars) and RCAN1^ox (dark bars) chromaffin cells were stained with the fluorescent mitochondrial membrane potential marker JC-1 under the following conditions: basal (30 cells), 56 mM K⁺ solution (30 cells), 500 nM Valinomycin (10 minutes/10 cells), and 100 μm H₂O₂ (60 minutes/9 cells). Error bars represent the SEM; ^∗𝑃<0.05.