RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells

Figure 6

PC12^RCAN1 cells exhibit reduced viability upon exposure to H₂O₂. Control (lights bars) and PC12^RCAN1 cells (dark bars) were exposed to increasing concentrations of H₂O₂ from 0–250 μm for 18 hours. At 50 μM and 100 μM H₂O₂, fewer PC12^RCAN1 cells were viable when compared to control PC12 cells under the same conditions. Data has been normalized to percentage of starting viable cells for each group and error bars represent the SEM. 𝑛=13 experiments in control and PC12^RCAN1 cells; ^∗𝑃<0.05 and ^∗∗𝑃<0.01.