RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells

Figure 7

Summative roles of RCAN1 in neurodegeneration and cell function. Elevated amyloid-β levels in neuronal cells can lead to elevated RCAN1 expression which inhibits calcineurin activity resulting in accumulation of hyperphosphorylated tau protein. This causes the formation of neurofibrillary tangles that lead to neurodegenerative disorders. We have further shown that elevated RCAN1 expression also leads to mitochondrial dysfunction, resulting in elevated intracellular oxidative stress, both of which are implicated in AD pathogenesis.