Review Article
Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases
Table 3
Changes in kynurenine pathway’s metabolites and enzymes with the age in rats [
178,
180,
185,
248].
| Metabolite/enzyme | Brain | Liver | Kidney |
| TRP | ↓ | ↓ | ↓ |
| TDO | ↓ | ↓ | ↓ |
| IDO | ↑ | ↓ | ↓ |
| KYN | ↑ | ↓ at 12 months No changes at 24 months | ↓ at 12 months ↑ at 24 months |
| KATs | ↑ | No changes | ↑ |
| KYNA | ↑ | No changes | ↑ |
| KMO | | ↓ | ↓ |
| Kynureninase | | ↓ | ↓ |
| 3-Hydroxyanthranilate 3,4-dioxygenase | | ↑ | ↑ |
| Aminocarboxymuconate-semialdehyde decarboxylase (ACMSD) | | ↑ | ↑ |
| QPRT | ↓ | ↓ | ↑ |
| QUIN | ↑ | ↑ | ↓ at 12 months No changes at 24 months |
| PIC | ↑ | ↑ | ↓ at 12 months No changes at 24 months |
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