Research Article

SIRT1 Functions as an Important Regulator of Estrogen-Mediated Cardiomyocyte Protection in Angiotensin II-Induced Heart Hypertrophy

Figure 5

SIRT1 participates in MAPK phosphorylation and cell apoptosis signal regulation.Western blot and average data of SIRT1, p-AMPK, AMPK, cleaved caspase-3, and GAPDH in the NRVMs treated by ethanol (dissolvent control group), 17-estradiol, AngII, or AngII + ICI182,780 (ethanol: EtOH; 17-estradiol: E2; ethanol + AngII: EtOH + A; E2 + AngII; ethanol + AngII + ICI; E2 + AngII + ICI; , , , and ).