Human AP Endonuclease 1: A Potential Marker for the Prediction of Environmental Carcinogenesis Risk

Figure 1

Multifunction of APE1/Ref1. APE1 has varied and independent functions and has an essential role in maintaining cellular stability. APE1 enzymatically restores damaged DNA bases and interacts with other proteins involved in DNA repair. APE1 regulates redox status of various transcription factors including AP-1 and p53 with its Cys residue. The crystal structure of APE1 (PDB ID : 1HD7) was identified by Beernink et al. [12].