Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis
Figure 2
Expression of GPX3 mRNA is downregulated in IBC. Blot represents the mean fold change of GPX3 mRNA measured by RT-PCR in normal breast tissues, IBC and non-IBC carcinoma tissues. Statistical analysis revealed a significant increase in expression of GPX3 mRNA in normal breast tissues compared to non-IBC and IBC carcinoma tissues ( and , resp.). In carcinoma tissues of non-IBC patients, the level of expression of GPX3 mRNA is significantly higher () than that of IBC. Results are representative of at least three independent experiments. Data are expressed as mean ± SD and value was determined by Student’s -test.
