Exercise-Induced Neuroprotection of Hippocampus in APP/PS1 Transgenic Mice via Upregulation of Mitochondrial 8-Oxoguanine DNA Glycosylase

Figure 5

Effect of 20 weeks of treadmill exercise training on mitochondrial ROS generation (a) and 8-oxodG content of the mtDNA (b). Group identities are the same as those in Figure 1. Hippocampus from four mice in one group was pooled and mitochondria were isolated for each sample, for all independent experiments. Data are mean ± SD. ; , compared to SED-WT group. ; , compared to SED-Wt or SED-Tg group. n.s., nonsignificant.

(a)

(b)