Anandamide Protects HT22 Cells Exposed to Hydrogen Peroxide by Inhibiting CB1 Receptor-Mediated Type 2 NADPH Oxidase

Figure 2

AEA increased the metabolic activity of HT22 cells exposed to H₂O₂ in a dose-dependent manner. (a) The correlation between the H₂O₂ concentration and cell metabolic activity. HT22 cells were exposed to different concentrations of H₂O₂ for 3 h (𝑛=8). (b) AEA increased the cell metabolic activity of HT22 cells exposed to 200 μM H₂O₂ for 3 h (𝑛=8). Results are expressed as means ± SD, ^∗𝑃<0.05, ^∗∗∗𝑃<0.001 versus the control (no H₂O₂, and no AEA), ^#𝑃<0.05 versus the cells exposed to H₂O₂ alone.

(a)

(b)