High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac Ischemia/Reperfusion Injury due to Induction of Oxidative Damage in Coronary Artery

Figure 4

Total CK-MB (a), LDH (b), and cTnI (c) releases at baseline and after 2-hour reperfusion (). (d) Representative photomicrographs of H&E-stained left ventricular tissue section (). Scale bar: 100 m. (e) Pathological scores for hyaline change, cloudy swelling, fatty change, inflammatory infiltration, perinuclear halo, interstitial edema, and acute myocardial necrosis. Values are presented as mean ± SD. , , and versus the 0.1% PolyPHb group; versus the I/R group. CK-MB: creatine kinase-MB; LDH: lactate dehydrogenase; cTnI: cardiac troponin-I; H&E: hematoxylin and eosin.

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