Vitamin A and Retinoids as Mitochondrial Toxicants

Table 1

Summary of the in vivo effects of subacute vitamin A supplementation on mitochondrial membranes parameters.

Sample	Lipid peroxidation	Protein carbonylation	Protein nitration	Protein thiol content	Reference
Cerebral cortex			Not measured		[65]
Cerebellum			Not measured		[65]
Substantia nigra		Not measured	Not measured	Not measured	[67]
Striatum		Not measured	Not measured	Not measured	[67]
Hypothalamus		Not measured	Not measured	Not measured	[68]
Frontal cortex				Unaltered	[69, 70]
Hippocampus				Unaltered	[70, 71]
Liver			Not measured	Unaltered	[72, 73]
Heart	Not measured	Not measured		Not measured	[74]
Lung				Unaltered	[75]

Adult male rats were treated with vitamin A supplementation (1,000–9,000 IU/kg/day) subacutely (see text for details).