Tocotrienol Rich Palm Oil Extract Is More Effective Than Pure Tocotrienols at Improving Endothelium-Dependent Relaxation in the Presence of Oxidative Stress

Table 2

The effect of various combinations of α-tocopherol (TC) and α-, δ-, and γ-tocotrienols (T3) on ACh-induced endothelium-dependent and SNP-induced endothelium-independent relaxation of rat aortae in the presence of pyrogallol- (P-) induced oxidative stress.

		ACh			SNP
		pEC50 (M)	(%)		pEC50 (M)	(%)
Treatment
Control	6	−7.20 ± 0.15	93 ± 12	5	−8.68 ± 0.15	96 ± 2
Pyrogallol	5	−6.77 ± 0.07	50 ± 4^#	5	−8.48 ± 0.09	100 ± 2
Pyrogallol + tocomin 10^−4 mg/mL	5	−7.19 ± 0.13	80 ±	5	−8.34 ± 0.16	105 ± 5
P + T3 (α + δ + γ) + (α-TC) 10^−4 mg/mL	5	−7.02 ± 0.11	73 ±	4	−8.49 ± 0.17	102 ± 2
P + T3 (α + γ) 10^−4 mg/mL	6	−6.86 ± 0.29	65 ± 6^#	5	−8.20 ± 0.21	102 ± 1
P + T3 (α + δ + γ) 10^−4 mg/mL	3	−6.57 ± 0.23	61 ± 13^#	5	−8.12 ± 0.08	103 ± 2

Tocotrienol isomers and α-tocopherol were present in the proportions found in tocomin (i.e., is α-T3- 20%, δ-T3 10%, and γ-T3 50% and α-TC 20%).
^#Significantly different to control .
Significantly different to pyrogallol .
Sidak’s multiple comparison test.