|
Compounds | H2S release mechanisms | Therapeutic effects | References |
|
GYY4137 | Hydrolysis | Vasodilation | [86] |
Anti-inflammation | [19] |
Anticancer | [87] |
Protection of mitochondrial function | [88] |
Regulation of oviductal embryo transport and myometrial contractility | [89, 90] |
Antithrombotic | [91] |
|
ADT | Metabolized by carboxylesterases | Neuroprotection against oxidative stress | [92] |
Protection of blood-brain barrier integrity | [55] |
|
ADT-OH | Metabolized by carboxylesterases | Neuroprotection against oxidative stress | [92] |
Vasorelaxation | [93] |
Antineuroinflammation | [94] |
|
AP39 | Metabolized by carboxylesterases | Protection against oxidative mitochondrial DNA damage | [95] |
|
S-Aroylthiooximes | Hydrolysis | Unknown | [96] |
|
S-Propargyl-cysteine | Hydrolysis | Angiogenesis promotion | [97] |
Anticancer | [98] |
Cardioprotection | [99] |
Anti-inflammation | [100] |
|
SG-1002 | Activation after oral administration | Cardioprotection | [101] |
|
4-Hydroxythiobenzamide | Hydrolysis | Improvement of wound healing | [102] |
|
Arylthioamides | Thiol activation | Unknown | [103] |
|
N-(benzoylthio)benzamides | Hydrolysis | Unknown | [104] |
|
S-Propyl cysteine | Hydrolysis | Cardioprotection | [99] |
|
N-Acetylcysteine | Hydrolysis | Protection against oxidative stress | [105] |
|
N-Acetylcysteine ethyl ester | Hydrolysis | Protection against oxidative stress | [105] |
|
SAC* | Hydrolysis | Protection against oxidative stress | [99] |
|
PhNCS | Thiol activation | Unknown | [106] |
|
PhNCS-COOH | Thiol activation | Unknown | [106] |
|
Lawesson’s reagent | Hydrolysis | Anti-inflammation | [107] |
Protection against gastric damage | [108] |
|
Dithioperoxyanhydrides | Thiol activation | Vasorelaxation | [35] |
|
Thioglycine | Bicarbonate activation | Unknown | [109] |
|
L-Thiovaline | Bicarbonate activation | Unknown | [109] |
|
Thioamino acids | Bicarbonate activation | Vasorelaxation | [109] |
|
Phosphorodithioates | Hydrolysis | Protection against oxidative stress | [35] |
|
S-SH compounds | Thiol activation | Myocardial I/R protection | [110] |
|
N-(acylthio)-benzamides | Thiol activation | Unknown | [104] |
|
H2S photo-donor 5 | Light activation | Unknown | [111] |
|
gem-Dithiol compounds | Light activation | Unknown | [35] |
|
Allyl isothiocyanate | Thiol activation | Unknown | [112] |
|
Benzyl isothiocyanate | Thiol activation | Unknown | [112] |
|
4-Hydroxybenzyl isothiocyanate | Thiol activation | Unknown | [112] |
|
Erucin | Thiol activation | Unknown | [112] |
|
Sinigrin | Hydrolysis | Unknown | [112] |
|
Poly(ethylene glycol)-ADT | Metabolized by carboxylesterases | Unknown | [113] |
|
S-memantine | Thiol activation | Protection against ischemic neuronal death | [114] |
|
ACS1 | Metabolized by carboxylesterases | Neuroprotection | [115] |
Anticancer | [116] |
|