Daily Oxygen/O₃ Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise

Table 3

Physical, hemodynamic, and morphometric parameters recorded at the end of the 11 weeks of protocol in rats subjected to a prolonged high intensity exercise.

	ET + O2	ET + O2/O3 100	ET + O2/O3 150	ET + O2/O3 300
Physical parameters
Body weight (g)	272 ± 18.5	271 ± 14.8	268.7 ± 14.4	260 ± 15.1
Heart wt (g)	0.86 ± 0.11	0.79 ± 0.09	0.75 ± 0.08	0.735 ± 0.07
Tibial length (cm)	3.9 ± 0.04	3.93 ± 0.03	3.98 ± 0.02	4.1 ± 0.03
Heart weight/tibial length (g/cm)	0.22 ± 0.04	0.20 ± 0.04	0.19 ± 0.02	0.18 ± 0.02
Hemodynamic parameters
MAP (mmHg)	125 ± 1.3	123.3 ± 1.1	119 ± 1.5	111 ± 1.2
Heart rate (bpm)	436 ± 7.4	431 ± 7.3	413 ± 7.5	403 ± 7.9
Morphometric parameters
LV mass (g)	0.49 ± 0.07	0.35 ± 0.08	0.30 ± 0.05	0.28 ± 0.03
RWT	0.045 ± 0.004	0.045 ± 0.004	0.036 ± 0.003	0.031 ± 0.002
Systolic function
LVFS (%)	49 ± 1.1	49.6 ± 1.4	53.7 ± 1.5	53.8 ± 1
LVEF %	58 ± 1	59 ± 2.5	62 ± 1.6	64 ± 1.5
VCF (circ./sec)	0.0061 ± 0.0003	0.0062 ± 0.0002	0.0070 ± 0.0002	0.0074 ± 0.0003
Diastolic function
IVRT (ms)	29 ± 2.8	29.5 ± 2	34.5 ± 1.2	39 ± 1.8
ratio (ms)	2.4 ± 0.06	2.42 ± 0.05	2.54 ± 0.04	2.63 ± 0.05
Global index
MPI	0.74 ± 0.03	0.75 ± 0.06	0.81 ± 0.02	0.85 ± 0.02

MAP = mean arterial pressure; LV = left ventricular mass and relative wall thickness (RWT); EF = ejection fraction; FS = fractional shortening and velocity of circumferential fiber shortening (VCF); IVRT = absolute left ventricular isovolumetric relaxation time; ratio = ratio of maximal early diastolic peak velocity/late peak velocity of mitral flow. MPI = myocardial performance index; ms = milliseconds. Significant differences with respect to ET + O₂ are shown as p < 0.05 and p < 0.01. ET = exercise trained rats running on treadmill; ET + O₂/O₃ 100 = rats receiving exercise + 100 g/kg oxygen/O₃; ET + O₂/O₃ 150 = rats receiving exercise + 150 g/kg oxygen/O₃; ET + O₂/O₃ 300 = rats receiving exercise + 300 g/kg oxygen/O₃.