Serum Oxidative Stress Markers and Genotoxic Profile Induced by Chemotherapy in Patients with Breast Cancer: A Pilot Study

Table 3

Biomarkers levels of oxidative stress in antioxidant enzymatic system of patients with breast cancer before (C0), during (C2), and after chemotherapy (C4) and control group.

Groups	TBARS levels; (nM/mg de protein)	content; (µM/mg protein)	GSH concentration; (U/g protein)
Control	0.37 ± 0.09	0.16 ± 0.05	36.13 ± 7.65
C0	1.42 ± 0.45^a	1.16 ± 0.62^a	24.94 ± 1.51^a
C2	4.76 ± 0.68^a,b	1.81 ± 0.02^a,b	19.30 ± 0.74^a,b
C4	11.98 ± 0.65^a.b,c	3.49 ± 0.07^a,b,c	17.75 ± 0.46^a,b

TBARS: thiobarbituric acid reactive substances levels, : nitrite content, and GSH: reduced glutathione concentration. Values represent mean ± S.E.M. ^a when compared with control group (CG) by ANOVA followed by -Student-Newman-Keuls. ^b when compared with C0 group (before chemotherapy) and ^c when compared with C2 group (second cycle of chemotherapy).