Epigallocatechin-3-Gallate Enhances the Therapeutic Effects of Leptomycin B on Human Lung Cancer A549 Cells

Figure 5

Hypothesis of EGCG on LMB metabolisms. LMB is possibly metabolized by the Phase I enzyme, CYP3A4, followed by Phase II enzymes. EGCG contributes to the formation of ROS, as well as inhibiting Phase I and II enzymes in A549 cells exposed to LMB + EGCG. induction; ⊥ inhibition.