Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy?

<div>Neurotransmitters in synapse. Molecules of NT are synthesized from their substrates by enzymes. NT are stored in vesicles. Vesicles after action potential fuse with presynaptic membrane and NT are released into synapse cleft. Released NT are linked to postsynaptic receptors and signal is transferred <svg height="12.0395pt" id="M1" style="vertical-align:-2.3616pt" version="1.1" viewbox="-0.0498162 -9.6779 27.0256 12.0395" width="27.0256pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M300 -147C201 -63 143 98 143 270S200 602 300 686L282 710C136 610 70 450 70 271V270C70 89 136 -72 282 -170L300 -147Z" id="g113-41"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="346" vert-adv-y="346"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,6.959,0)"><path d="M901 255C861 290 790 361 716 442L694 427L796 280H69V230H796L694 83L716 68C790 149 861 220 901 255Z" id="g117-148"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="954" vert-adv-y="954"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,22.155,0)"><path d="M275 270C275 450 212 609 64 710L45 686C145 604 203 442 203 270S147 -63 45 -147L64 -170C213 -68 275 89 275 270Z" id="g113-42"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="346" vert-adv-y="346"></glyph.data></g></svg> to postsynapse. NT can be reuptaken by autoreceptor and neurotransmission is inhibited <svg height="12.0395pt" id="M2" style="vertical-align:-2.3616pt" version="1.1" viewbox="-0.0498162 -9.6779 22.4836 12.0395" width="22.4836pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M300 -147C201 -63 143 98 143 270S200 602 300 686L282 710C136 610 70 450 70 271V270C70 89 136 -72 282 -170L300 -147Z" id="g113-41"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="346" vert-adv-y="346"></glyph.data></g><g transform="matrix(.0136,0,0,-0.0136,4.688,0)"><path d="M901 255C854 296 792 359 716 442L694 427L796 280H731V230H796L694 83L716 68C792 151 854 214 901 255ZM223 280H69V230H223V280ZM435 280H307V230H435V280ZM647 280H519V230H647V280Z" id="g185-45"></path><glyph.data ascent="989" descent="-303" horiz-adv-x="954" vert-adv-y="954"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,17.613,0)"><path d="M275 270C275 450 212 609 64 710L45 686C145 604 203 442 203 270S147 -63 45 -147L64 -170C213 -68 275 89 275 270Z" id="g113-42"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="346" vert-adv-y="346"></glyph.data></g></svg>. Reuptaken NT can be enzymatically degraded (MAO). NT: neurotransmitter; MAO: monoaminooxidase.</div>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy? 