Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection

Table 2

Adenylyl cyclase (AC) isoforms, which protect against oxidative stress using the SIRT1/FoxO3/MnSOD pathway.

	AC 1	AC 2	AC 3	AC 4	AC 5	AC 6	AC 7	AC 8	AC 9
Oxidative stress protection	+	?	?	?	+	?	?	?	?
SIRT 1	?	?	?	?	+	−	?	?	?
FoxO3	?	?	?	?	+	?	?	?	?
MnSOD	?	?	?	?	+	−	?	?	?

+ Positive, − negative, and ? unknown.