Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study

Table 4

Cox analysis of the cumulative relative risk (RR) of death for pretreatment protocol, including 95% confidence interval (CI), of animals exposed to the paraoxon (POX) and adjusted for POX dose (high/low).

Groups	RR ± SD	95% CI	Significance
POX only	1	0-0	—
PAM before POX	0.34 ± 0.19	0.04–0.64
NAC before POX	1.31 ± 0.24	0.93–1.70	NS
NAC before (POX + PAM)	0.63 ± 0.15	0.39–0.86
POX + PAM	0.47 ± 0.17	0.20–0.74
GSH before (POX + PAM)	0.93 ± 0.30	0.45–1.41	NS
GSH before POX	0.84 ± 0.39	0.94–1.48
AA before; (POX + PAM)	1.29 ± 0.18	1.01–1.57
AA before POX	1.09 ± 0.30	0.00–4.08	NS