Cytokine Dysregulation in MECP2- and CDKL5-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and ω-3 PUFAs

Figure 3

Circulating IL-17A, IL-22, TGF-β1, and IL-37 in MECP2- and CDKL5-mutated Rett patients before and after ω-3 PUFAs supplementation. Data are expressed as means ± standard deviations. Asterisks denote significant post hoc pairwise tests (). Note: levels of IL-10 are shown in Figure 2 since IL-10 is considered as both Th2 cytokine and T-reg cytokine. The dashed line denotes upper range limit as obtained from manufacturer’s data sheet or from published literature. For TGF-β1, normal range is indicated by dashed lines (upper and lower range limits). For IL-37, normal range is referred to in literature [58].

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