Cytokine Dysregulation in <i>MECP2</i>- and <i>CDKL5</i>-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and <i>ω</i>-3 PUFAs

<div>Schematic overview of the known effects of cytokines on immune and nonimmune cells. Blue font indicates anti-inflammatory effects. Red font indicates proinflammatory/activation effects. Relationships were reconstructed on the basis of literature [<a href="/journals/omcl/2015/421624/#B61">61</a>, <a href="/journals/omcl/2015/421624/#B62">62</a>, <a href="/journals/omcl/2015/421624/#B65">64</a>, <a href="/journals/omcl/2015/421624/#B67">66</a>]. The modulatory effects of MeCP2 are referred to in [<a href="/journals/omcl/2015/421624/#B27">27</a>, <a href="/journals/omcl/2015/421624/#B28">28</a>, <a href="/journals/omcl/2015/421624/#B30">30</a>]. Th1: T helper 1 cell; Th2: T helper 2 cell; Th17: T helper 17 cell; T-reg: T-regulatory cell, NK cell: natural killer cell; DC: dendritic cell; PMN: polymorphonuclear leukocyte.</div>

Oxidative Medicine and Cellular Longevity

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Figure 9

Figure 9: Cytokine Dysregulation in <i>MECP2</i>- and <i>CDKL5</i>-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and <i>ω</i>-3 PUFAs 

Figure 9 | Cytokine Dysregulation in MECP2- and CDKL5-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and ω-3 PUFAs 