Cytokine Dysregulation in MECP2- and CDKL5-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and ω-3 PUFAs

Table 1

Correlation coefficients for the relationships between clinical severity, inflammation, redox status, and circulating cytokine.

	Clinical severity (CCSS)	ESR	P-NBPI	IE-NPBI	F2-IsoPs	F4-NeuroPs	F2-dihomo-IsoPs	GSH/GSSG ratio
Clinical severity (CCSS)	—
ESR	—	—
TNF-α
IFN-γ			−0.091	−0.154	−0.088			−0.066
IL-1β		−0.117		0.091	0.145	−0.101
IL-12p70
IL-4				0.456				−0.233
IL-5	0.006	0.024	0.144	0.022		0.052	−0.030
IL-6	0.002	0.138	−0.042	−0.063	0.052	0.105	0.012
IL-10		−0.108		0.087
IL-13	−0.068	−0.071	−0.033	−0.066	0.073
IL-33	0.080			0.113			0.149
IL-17A
IL-22
TGF-β1			0.099	−0.043	−0.074			0.010
IL-37
IL-8	0.173							−0.151
IP-10	−0.110
I-TAC
RANTES	0.012		−0.134	−0.102	−0.249
IL-4/IFN-γ
IL-5/IFN-γ								−0.133
IL-6/IFN-γ	0.174			0.128
IL-10/IFN-γ	−0.141	−0.032		0.098		−0.132
IL-4/TNF-α			−0.115				−0.117	0.008
IL-5/TNF-α			−0.134		−0.149			−0.005
IL-6/TNF-α	−0.124	−0.098	−0.113		−0.103	−0.149	−0.127	−0.111
IL-10/TNF-α		−0.065	0.023	−0.055	0.059	−0.109	−0.137	−0.127

Data are expressed as correlation coefficients. Bold characters indicate statistically significant associations. Asterisks denote values: ; ; . CCSS: compressed clinical severity score [46]; ESR: erythrocyte sedimentation rate; P-NPBI: plasma non-protein-bound iron; F₂-IsoPs: plasma F₂-isoprostanes; F₂-dihomo-IsoPs: plasma F₂-dihomo-isoprostanes; F₄-NeuroPs: plasma F₄-neuroprostanes; IE-NBPI: intraerythrocyte non-protein-bound iron; GSH: reduced glutathione; GSSG: oxidized glutathione.