Oxidative Medicine and Cellular Longevity / 2015 / Article / Tab 2 / Research Article
Cytokine Dysregulation in MECP2 - and CDKL5 -Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and ω -3 PUFAs Table 2 Relationship between clinical severity, redox status, subclinical inflammation, and circulating cytokines for the whole population: results of a stepwise multiple regression analysis.
Dependent variable Final stepwise model Multiple correlation coefficient
Residual SD
Significance of Selected predictor variables P value
Clinical severity46 ] (+) TNF-α 0.406 <0.0001 0.490 0.476 0.699 2.66 35.72 <0.001 (+) IL-17A 0.235 0.0037 (+) IL-4 0.362 <0.0001 (−) IL-12p70 0.581 <0.0001
Clinical severity46 ] (−) GSH/GSSG 0.779 <0.0001 0.809 0.805 0.899 1.59 220.39 <0.001 (+) F4 -NeuroPs 0.235 0.0029 (+) F2 -IsoPs 0.184 0.0205 ESR (+) IL-17A 0.319 <0.0001 0.304 0.292 0.552 10.84 25.38 <0.001 (+) IL-4/IFN-γ 0.475 0.0009 P-NPBI (+) TNF-α 0.532 <0.0001 0.563 0.556 0.750 0.18 74.79 <0.001 (−) I-TAC 0.358 0.0001 F2 -IsoPs (+) TNF-α 0.383 <0.0001 0.581 0.570 0.762 12.93 53.23 <0.001 (+) IL-37 0.285 0.0018 (−) I-TAC 0.434 <0.0001 F2 -dihomo-IsoPs (−) IL-22 0.596 <0.0001 0.711 0.704 0.843 9.95 94.52 <0.001 (+) IL-4/IFN-γ 0.260 0.0047 (+) IL-17A 0.194 0.0359 F4 -NeuroPs (−) IL-22 0.553 <0.0001 0.874 0.870 0.935 2.26 197.65 <0.001 (+) IL-4/IFN-γ 0.247 0.0074 (+) IL-37 0.201 0.0235 (−) IL-12p70 0.606 <0.0001 IE-NPBI (+) TNF-α 0.493 <0.0001 0.440 0.431 0.664 0.32 48.02 <0.001 (−) I-TAC 0.221 0.0136 GSH/GSSG ratio (+) IL-22 0.678 <0.0001 0.804 0.797 0.897 1.89 117.05 <0.001 (−) IL-37 0.247 0.0076 (−) RANTES 0.476 <0.0001 (+) I-TAC 0.684 <0.0001
Plus and minus signs in brackets indicate positive or negative associations. CCSS: compressed clinical severity score [46 ]; ESR: erythrocyte sedimentation rate; P-NPBI: plasma non-protein-bound iron; F2 -IsoPs: plasma F2 -isoprostanes; F2 -dihomo-IsoPs: plasma F2 -dihomo-isoprostanes; F4 -NeuroPs: plasma F4 -neuroprostanes; IE-NBPI: intraerythrocyte non-protein-bound iron; GSH: reduced glutathione; GSSG: oxidized glutathione.
