Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation

Figure 3

Loss of high frequency information (bands) directly indicates loss of typical sarcomere ladder structure in DCM hearts. Sarcomere fine structure in images from Figure 2(d) for DCM and WT heart sections is traced by drawing line intensity profiles across the cellular structures. (a) Loss of cellular structure in DCM (right) compared to WT (left) heart sections is indicated by drawing a single line from the inner chamber, which is (d) represented by line intensity profiles for both WT (left) and DCM (right) sections. (b) Loss of cellular structure is further indicated by multiple line profiles drawn left to right in DCM (right) compared to WT (left) heart sections, which is (e) represented by line intensity profiles (1–4) for both WT (left) and DCM (right) sections. (c) Sarcomere area imaging in WT (left) and DCM (right) hearts.

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