Glutathione Suppresses Cerebral Infarct Volume and Cell Death after Ischemic Injury: Involvement of FOXO3 Inactivation and Bcl2 Expression

Figure 1

Measurement of infarct volume in MCAO rat brain at reperfusion 24 hr after MCAO injury. (a) At reperfusion 24 hr after MCAO injury, TTC staining showed that white areas were damaged by ischemic injury. White areas reduced more than 2-fold changes in the GSH treatment group compared to experimental control (EC) group. (b) Brain edema (%) was measured at reperfusion 24 hr after MCAO injury. The quantitative graph shows that brain edema was significantly reduced in GSH treatment group compared with EC group. Each experiment included 5 repeats per animal. Data were expressed as mean ± S.E.M. Statistical significance with EC group was determined by -test. Differences were considered significant at . EC: experimental control; reperfusion 24 hr after MCAO injury group, GSH: GSH treatment and reperfusion 24 hr after MCAO injury group.

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