Doses of Quercetin in the Range of Serum Concentrations Exert Delipidating Effects in 3T3-L1 Preadipocytes by Acting on Different Stages of Adipogenesis, but Not in Mature Adipocytes

Table 2

Relative triacylglycerol content (arbitrary units) after quercetin treatment in maturing preadipocytes and mature adipocytes.

C

Q0.1

Q0.5

Q1

Q2

Q5

Q10

Stage of adipogenesis

Whole adipogenesis (d0–d8)

100 ± 5.1

77.95 ± 12.8

0.09

75.57 ± 8.6

<0.01

58.4 ± 8.6

<0.001

81.3 ± 7.4

<0.05

79.6 ± 7.2

<0.05

62.9 ± 10.2

<0.01

Early stage (day 0–60 hours)

100 ± 6.9

86.0 ± 5.7

0.09

95.3 ± 7.3

ND

Late stage (60 hours–d8)

92.2 ± 5.6

ND

75.9 ± 10.5

<0.05

Mature adipocytes (d12 for 24 h)

100 ± 6.3

109.3 ± 34.0

ND

86.2 ± 3.4

0.07

79.3 ± 12.8

0.10

76.3 ± 4.8

<0.01

C = control; ND = no difference, Q0.1 = 0.1 M of quercetin, Q0.5 = 0.5 M of quercetin, Q1 = 1 M of quercetin, Q2 = 2 M of quercetin, Q5 = 5 M of quercetin, and Q10 = 10 M of quercetin.
Values are means ± SEM. Comparisons between each treatment and the controls were analyzed by Student’s -test. The difference was established at .