Reactive Oxygen Species in Mesenchymal Stem Cell Aging: Implication to Lung Diseases

Figure 2

The role of ROS in COPD and ARDS. In COPD, aging and cigarette smoke increase the generation of ROS, leading to the upregulation of inflammatory signaling in alveolar type II cells. In ARDS, endotoxin and shock induce the infiltration of neutrophils into interstitial, and chromatin changes are involved. In the pathogenesis of COPD and ARDS, ROS-induced neutrophils are recruited in alveoli, and production of ROS is rapidly accumulated, derived from infiltrated neutrophils, and activated macrophages.