Neuroprotective Effect of Dexmedetomidine on Hyperoxia-Induced Toxicity in the Neonatal Rat Brain

Figure 3

Alteration of lipid peroxidation by hyperoxia in the immature brain. Hyperoxia lead to a significant increase of MDA levels after 24 h of oxygen exposure (black bar), whereas a single DEX application of 5 or 10 μg/kg (hatched grey bars) before hyperoxia exposure reduced these levels significantly. Bars represent mean + SEM, per group, ^* and ^*** versus normoxia/control; ^## and ^### versus hyperoxia.