Renal Oxidative Stress Induced by Long-Term Hyperuricemia Alters Mitochondrial Function and Maintains Systemic Hypertension
Table 1
Functional and mitochondria data in long-term follow-up groups.
Parameter
Vehicle
OA
OA + Tempol
OA + AP
Plasma UA (mol/L)
44 ± 2
110 ± 27a
117 ± 36a
26 ± 6b
Systolic blood pressure (mmHg)
125 ± 4
144 ± 7a
121 ± 5b
129 ± 8b
RPF (mL/min)
3.7 ± 0.3
2.7 ± 0.4a
4.4 ± 0.3ab
4.1 ± 0.3b
RVR (mmHg/mL/min)
19 ± 1
28 ± 5a
15 ± 1b
17 ± 3b
Mitochondrial respiration malate/glutamate
State 3 (ng AtO2/min/mg prot)
83 ± 18
43 ± 13a
149 ± 44ab
114 ± 43b
State 4 (ng AtO2/min/mg prot)
34 ± 6c
30 ± 11c
57 ± 21
37 ± 5c
Mitochondrial respiration succinate/rotenone
State 3 (ng AtO2/min/mg prot)
170 ± 60
84 ± 36a
238 ± 53b
237 ± 60b
State 4 (ng AtO2/min/mg prot)
70 ± 20
53 ± 25
87 ± 20b
65 ± 14
Data are expressed as mean ± SD. RPF = renal plasma flow; RVR = renal vascular resistance. a < 0.05 versus control; b < 0.05 versus OA; c < 0.05 versus Tempol.