A Yeast/Drosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency

Figure 1

Drugs ability to improve the fitness of frataxin-deficient yeast cells. Pairwise analysis of the growth of the yfh1 cells in two independent experiments, using the full set of compounds from the French National Chemical Library (5500 compounds) and the Prestwick collection (880 compounds). The regions of the graph circled with dotted lines representing the results of growth improvement in only one condition are maybe therefore attributed to growth of extragenic suppressors. Compounds within the area circled with a solid line were typical of drugs entering the secondary screening in the yeast assay.