A Novel Antioxidant Multitarget Iron Chelator M30 Protects Hepatocytes against Ethanol-Induced Injury

Figure 2

M30 improved cellular apoptosis. (a) Apoptotic ratio after various treatments. (b) Activity of caspase-3/7 of hepatocytes after various treatments. (c) Cellular Bcl-2 and Bax1 mRNA change after various treatments. Data from each group () were expressed as means ± SEM. Statistical comparison between groups was done using the Kruskal-Wallis test followed by Dunn’s post hoc test to detect differences in all groups. “” means significantly different from control group (). “” means significantly different from control group (). “” means significantly different from control group (). “” means significantly different from ethanol exposure group (). “” means significantly different from ethanol exposure group (). “” means significantly different from ethanol exposure group (). EtOH, ethanol, M30, vehicle M30 treatment, E + M30, ethanol + M30 cotreatment.

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