A Novel Antioxidant Multitarget Iron Chelator M30 Protects Hepatocytes against Ethanol-Induced Injury

Figure 6

Role of the AC/cAMP/PKA pathway in NLRP3 inflammasome activation. (a-b) Changes of secreted IL-1β and IL-18 after ethanol exposure, M30 pretreatment, and/or AC agonist forskolin/inhibitor SQ22536. (c-d) Changes of secreted IL-1β and IL-18 after ethanol exposure, M30 pretreatment, and/or cAMP analogue db-cAMP/PKA inhibitor H89. Data from each group () were expressed as means ± SEM. Statistical comparison between groups was done using the Kruskal-Wallis test followed by Dunn’s post hoc test to detect differences in all groups. “” means significantly different from control group (). “” means significantly different from control group (). “” means significantly different from control group (). “” means significantly different from ethanol exposure group (). “” means significantly different from ethanol exposure group (). “” means significantly different from ethanol exposure group ().

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