Total Glucosides of Danggui Buxue Tang Attenuate BLM-Induced Pulmonary Fibrosis via Regulating Oxidative Stress by Inhibiting NOX4

Figure 5

DBTG attenuates BLM-induced rats PF via regulating oxidative stress by inhibiting NOX4. In this study, oxidative stress happened in BLM-induced PF. And then, a lot of ROS was synthesized by NOX4 to promote the expression of TGF-β1 and its downstream protein α-SMA that increased the degree of PF. DBTG could inhibit NOX4 to reduce ROS and control the level of oxidative stress. As the level of oxidative stress was regulated, the expression of TGF-β1 and expression of α-SMA were both decreased and, at last, the development of PF could be inhibited.