Potential Therapeutic Role of L-Carnitine in Skeletal Muscle Oxidative Stress and Atrophy Conditions

Figure 2

CARN action during C2C12 proliferation phase. (a) Growth curve: CARN did not significant modify C2C12 proliferative potential and did not induce cytotoxic effects. (b) CARN treatment does not modify p53 protein levels while it increases MyoD protein content after 3 days of treatment. (c) Phase contrast images reveal the morphological features of the cells in proliferation. Representative immunoblots of analyzed proteins are shown. Scale bar 200 μm. Significance: (a) DM versus GM and (b) p53 DM versus . MyoD: Anova test, GM versus , CARN versus , DM versus , CARN versus GM, and DM versus GM.

(a)

(b)

(c)