Effects of Ezetimibe/Simvastatin and Rosuvastatin on Oxidative Stress in Diabetic Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Table 2

Nerve conduction studies. Values of different nerve parameters are reported before and after treatment in all groups.

	PLACEBO			EZE/SIMV			ROSUV
	Baseline	Final		Baseline	Final		Baseline	Final
Lower limbs
Sural nerve
Lat (ms)	4.0 ± 0.5	3.6 ± 0.2	0.006	4.1 ± 0.4	3.7 ± 0.1	0.021	4.1 ± 0.6	3.8 ± 0.2	0.070
Amp (µV)	10.9 ± 12.0	15.9 ± 2.8	0.084	9.5 ± 3.2	14.8 ± 2.9	0.477	12.6 ± 6.6	15.2 ± 2.3	0.538
Peroneal nerve
Lat (ms)	3.8 ± 0.8	3.7 ± 0.2	0.207	3.7 ± 0.5	3.6 ± 0.2	0.210	3.6 ± 0.9	3.5 ± 0.1	0.810
Amp (mV)	4.7 ± 3.1	5.0 ± 0.5	0.191	4.5 ± 1.7	4.4 ± 0.4	0.835	4.7 ± 2.6	4.5 ± 0.5	0.296
Vel (m/s)	39.3 ± 4.4	40.6 ± 1.1	0.004	40.6 ± 3.8	41.5 ± 0.9	0.111	39.9 ± 4.1	40.0 ± 0.8	0.944
Tibiae nerve
Lat (ms)	4.2 ± 1.3	4.1 ± 0.2	0.395	4.4 ± 0.9	4.5 ± 0.3	0.562	4.3 ± 1.1	4.3 ± 0.2	0.776
Amp (mV)	8.4 ± 4.3	9.1 ± 1.2	0.070	8.3 ± 3.3	7.9 ± 0.7	0.390	8.2 ± 3.2	8.3 ± 0.9	0.972
Vel (m/s)	42.1 ± 5.4	43.1 ± 1.3	0.008	44.2 ± 5.2	45.0 ± 0.9	0.057	45.2 ± 6.3	44.4 ± 1.3	0.136
Upper limbs
Median motor nerve
Lat (ms)	4.6 ± 1.4	5.5 ± 0.5	0.655	6.5 ± 1.8	5.6 ± 1.0	0.655	4.4 ± 0.8	5.0 ± 0.1	0.317
Amp (mV)	6.0 ± 1.3	4.5 ± 0.9	0.180	6.5 ± 1.0	8.0 ± 0.8	0.655	9.2 ± 3.9	7.3 ± 1.4	0.180
Vel (m/s)	47.4 ± 5.9	45.7 ± 3.8	0.180	49.7 ± 3.8	51.2 ± 2.3	1.000	41.7 ± 3.5	51.3 ± 4.9	0.317
Median sensitive nerve
Lat (ms)	3.8 ± 0.6	3.7 ± 0.1	0.141	3.9 ± 0.6	4.3 ± 0.2^†	0.076	4.3 ± 0.7	4.2 ± 0.2	0.539
Amp (µV)	26.0 ± 14.5	26.4 ± 4.0	0.553	22.2 ± 14.0	18.3 ± 2.4	0.476	15.8 ± 6.4	21.6 ± 2.5	0.266
Vel (m/s)	52.2 ± 6.0	53.1 ± 1.3	0.195	51.1 ± 5.2	52.8 ± 1.3	0.083	52.8 ± 5.2	52.8 ± 1.5	0.778
Ulnar motor nerve
Lat (ms)	3.5 ± 0.6	3.2 ± 0.1	0.031	3.3 ± 0.3	3.4 ± 0.1	0.479	3.4 ± 0.4	3.3 ± 0.1	0.468
Amp (mV)	8.3 ± 2.7	8.2 ± 0.7	0.888	8.9 ± 2.7	8.0 ± 0.3	0.338	8.3 ± 1.6	8.1 ± 0.4	0.394
Vel (m/s)	51.2 ± 8.5	51.6 ± 2.0	0.776	55.0 ± 4.8	53.7 ± 1.3	0.198	54.0 ± 4.4	53.9 ± 1.1	0.649
Ulnar sensitive nerve
Lat (ms)	3.8 ± 0.8	3.6 ± 0.1	0.629	3.7 ± 0.4	3.8 ± 0.1	0.673	3.7 ± 0.7	3.7 ± 0.1	0.175
Amp (µV)	21.2 ± 23.9	21.5 ± 2.9	0.127	19.8 ± 12.6	19.5 ± 3.1	0.936	16.9 ± 7.7	17.8 ± 2.2	0.913
Vel (m/s)	53.7 ± 4.5	53.5 ± 1.5	0.463	55.5 ± 5.7	55.1 ± 1.2	0.380	54.3 ± 5.7	54.3 ± 1.1	0.448

Mean ± SEM, , versus placebo Mann-Whitney’s .