Genome-Wide Expression Profiling of Anoxia/Reoxygenation in Rat Cardiomyocytes Uncovers the Role of Mito<svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-4.1996pt" id="M1" height="15.332pt" version="1.1" viewBox="-0.0657574 -11.1324 35.4805 15.332" width="35.4805pt"><g transform="matrix(.017,0,0,-0.017,0,0)"><path id="g187-76" d="M699 0V35C659 41 632 57 591 109C519 200 445 301 381 397C426 443 468 491 527 545C582 597 623 609 685 615V650H425V615L443 613C490 607 492 592 468 561C435 516 395 467 328 399C298 368 273 352 252 346V516C252 602 260 608 331 615V650H37V615C112 608 121 602 121 516V134C121 48 111 42 39 35V0H338V35C261 42 252 48 252 134V314C267 316 280 310 301 280C372 176 455 59 498 0H699Z"/></g><g transform="matrix(.012,0,0,-0.012,12.108,4.134)"><path id="g187-66" d="M687 0V35C623 43 611 56 577 144C512 316 450 490 386 665L335 652L130 138C97 54 84 43 18 35V0H242V35C169 44 166 58 181 106C193 146 206 182 217 213H409C424 173 439 130 449 100C465 56 460 44 401 35V0H687ZM390 266H234C260 337 285 410 313 483H316L390 266Z"/></g><g transform="matrix(.012,0,0,-0.012,19.709,4.134)"><path id="g187-85" d="M616 481C611 545 606 633 605 675H580C563 656 549 650 523 650H121C92 650 79 653 64 675H39C37 624 31 551 27 478H64C77 528 89 562 106 579C120 596 138 606 221 606H255V133C255 48 245 42 161 35V0H487V35C399 42 389 48 389 133V606H434C493 606 518 601 536 583S568 531 580 479L616 481Z"/></g><g transform="matrix(.012,0,0,-0.012,27.408,4.134)"><path id="g187-81" d="M42 650V615C112 608 121 601 121 516V133C121 48 112 41 37 34V0H347V34C262 41 253 48 253 133V271L321 254C332 254 347 254 362 256C468 269 567 330 567 464C567 529 540 579 493 611C453 639 397 650 318 650H42ZM253 570C253 585 255 595 262 601C268 606 280 611 299 611C360 611 423 574 423 461C423 326 343 300 307 300C286 300 265 305 253 310V570Z"/></g></svg> in Energy Homeostasis

<div>Scheme of the molecular myocardial protective mechanism of mitoK<sub>ATP</sub> in myocardial A/R setting. MitoK<sub>ATP</sub> opening-up regulated the expression of<i> Mt-nd6</i>,<i> Idh2,</i> and<i> Acadl</i>. In addition, mitoK<sub>ATP</sub> opening may recruit DEGs to regulate PPAR signaling pathway, TCA, fatty acid metabolism, and proteasome pathways. Eventually, mitoK<sub>ATP</sub> opening resulted in an energy homeostasis in the adult rat A/R cardiomyocytes.</div>

Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Genome-Wide Expression Profiling of Anoxia/Reoxygenation in Rat Cardiomyocytes Uncovers the Role of Mito<svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-4.1996pt" id="M1" height="15.332pt" version="1.1" viewBox="-0.0657574 -11.1324 35.4805 15.332" width="35.4805pt"><g transform="matrix(.017,0,0,-0.017,0,0)"><path id="g187-76" d="M699 0V35C659 41 632 57 591 109C519 200 445 301 381 397C426 443 468 491 527 545C582 597 623 609 685 615V650H425V615L443 613C490 607 492 592 468 561C435 516 395 467 328 399C298 368 273 352 252 346V516C252 602 260 608 331 615V650H37V615C112 608 121 602 121 516V134C121 48 111 42 39 35V0H338V35C261 42 252 48 252 134V314C267 316 280 310 301 280C372 176 455 59 498 0H699Z"/></g><g transform="matrix(.012,0,0,-0.012,12.108,4.134)"><path id="g187-66" d="M687 0V35C623 43 611 56 577 144C512 316 450 490 386 665L335 652L130 138C97 54 84 43 18 35V0H242V35C169 44 166 58 181 106C193 146 206 182 217 213H409C424 173 439 130 449 100C465 56 460 44 401 35V0H687ZM390 266H234C260 337 285 410 313 483H316L390 266Z"/></g><g transform="matrix(.012,0,0,-0.012,19.709,4.134)"><path id="g187-85" d="M616 481C611 545 606 633 605 675H580C563 656 549 650 523 650H121C92 650 79 653 64 675H39C37 624 31 551 27 478H64C77 528 89 562 106 579C120 596 138 606 221 606H255V133C255 48 245 42 161 35V0H487V35C399 42 389 48 389 133V606H434C493 606 518 601 536 583S568 531 580 479L616 481Z"/></g><g transform="matrix(.012,0,0,-0.012,27.408,4.134)"><path id="g187-81" d="M42 650V615C112 608 121 601 121 516V133C121 48 112 41 37 34V0H347V34C262 41 253 48 253 133V271L321 254C332 254 347 254 362 256C468 269 567 330 567 464C567 529 540 579 493 611C453 639 397 650 318 650H42ZM253 570C253 585 255 595 262 601C268 606 280 611 299 611C360 611 423 574 423 461C423 326 343 300 307 300C286 300 265 305 253 310V570Z"/></g></svg> in Energy Homeostasis 

Oxidative Medicine and Cellular Longevity

Genome-Wide Expression Profiling of Anoxia/Reoxygenation in Rat Cardiomyocytes Uncovers the Role of Mito in Energy Homeostasis

Figure 6