GC-Rich Extracellular DNA Induces Oxidative Stress, Double-Strand DNA Breaks, and DNA Damage Response in Human Adipose-Derived Mesenchymal Stem Cells

Figure 1

Distribution of CpG-motifs and Gn-motifs () within the model DNA samples and within rDNA (transcribed region of human ribosomal repeat) that accumulates in circulating DNA of blood plasma. The digits indicate the nucleotide order number, while the vertical bar shows the motif location. For comparison, the figure also presents the distribution of the motifs within a randomly chosen fragment of genomic DNA with a total GC-content of 42%.