Pituitary Adenylate Cyclase-Activating Polypeptide Reverses Ammonium Metavanadate-Induced Airway Hyperresponsiveness in Rats

Table 3

PACAP’s regulatory effects on the enzymatic activity of the Mn-SOD and Cu/Zn-SOD isoforms in AMV-induced lung toxicity. Rats received AMV aerosols (AMV; 5 mg/m³/h) for 15 minutes followed or not by PACAP aerosols (AMV + P₃₈; 0.1 mM) for 10 additional minutes. Control rats (controls) received the vehicle only. Values are expressed as means ± SEM ( = 8 for each experimental group). versus control; versus control; ^## versus AMV in Tukey’s multiple comparison post  hoc test.

	Mn-SOD; (SOD units/min/mg)	Cu/Zn-SOD; (SOD units/min/mg)
Controls	0.97 ± 0.04	0.29 ± 0.04
AMV	0.36 ± 0.009	0.08 ± 0.01
AMV + P38	0.73 ± 0.01	0.08 ± 0.01