Research Article

Pituitary Adenylate Cyclase-Activating Polypeptide Reverses Ammonium Metavanadate-Induced Airway Hyperresponsiveness in Rats

Table 4

Effect of PACAP aerosols on adherent cell and nonadherent cell numbers in bronchoalveolar lavage fluids (BALF) of AMV-exposed rats. Rats received AMV aerosols (AMV; 5 mg/m3/h) for 15 minutes followed or not by PACAP aerosols (AMV + P38; 0.1 mM) for 10 minutes. Control rats (controls) received the vehicle only. Four hours after treatment, the treated rats were submitted to bronchoalveolar lavages. The numbers of adherent and nonadherent cells contained in BALF were further determined after 24 h of culture. Values are expressed as means ± SEM ( = 8 for each experimental group). versus control; ## versus AMV in Tukey’s multiple comparison post  hoc test.

Adherent cells (×106)Nonadherent cells (×106)

Controls2.54 ± 0.192.74 ± 0.39
AMV1.12 ± 0.165.39 ± 0.79
AMV + P380.64 ± 0.140.48 ± 0.13