An Organ System Approach to Explore the Antioxidative, Anti-Inflammatory, and Cytoprotective Actions of Resveratrol
Table 1
Approaches to enhance resveratrol’s bioavailability.
Strategy
Examples
Effect on absorption pharmacokinetics
Reference
Solubility
(1) SRT501 formulation: a mixture of micronized resveratrol with particle size <5 m, flavors, colors, and emulsifiers. (2) Using hydroxypropyl-β-cyclodextrin.
More than 4-fold increase in , AUC and 2-fold increase in . Significant increase in rate of absorption with a negligible impact on bioavailability.
(1) Coadministration with piperine, a polyphenol from black pepper. (2) Coadministration with quercetin, a plant flavonoid with potent antioxidant action.
1000% increase in and delaying the major glucuronide metabolite. Quercetin reduces the rate of resveratrol sulfate conjugation, but with no significant improvement on and AUC.